Eritrodermia em Recém-Nascidos

  • Ertythrodermia in Neonates
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      Neonates have impaired skin barrier function → higher risk of infection, hypernatremic dehydration, transcutaneous absorption of topical medications
    • Most likely genetic cause → identify mutation → next generation sequencing and whole exome sequencing
    • Dermatitides
      • Dermatite seborreica eritrodérmica - Leiner-Moussous syndrome
    • Psoriasis
    • Drug-induced
    • Ichthiosis
        • Ichthyosis | Ictioses | Disorders of Epidermal differentiation/Cornification
      • Congenital ichthyosiform erythroderma (presents as collodian baby)
      • Epidermolytic ichthyosis (presents as generalized erythyma with superimposed superficial blisters and erosions, may be misdiagnosed as SSSS or epidermolysis bullosa)
      • Netherton syndrome (presents as ichthyosiform erythroderma in neonates + trichorrhexis invaginata + elevated IgE + immune defect that may lead to lifethreatning infections)
    • Immunodeficiencies
    • Consequences of infections