Synonim
- Gammel’s disease
Mechanism: paraneoplastic phenomenon
- 🫁 Lung carcinoma >>> breast and esophageal carcinoma
- Outras causas: tuberculose pulmonar, ictiose, hiperqueratose palmo-plantar, hipereosinofilia
- Theory: auto-immune due to cross reactivity. Similar antigens in the bronchial wall and in the epidermis
Apresentação clínica
- Figurate erythema that is migratory and has concentric rings with wood-grain appearance
- Migrates fast up to 1cm per day
- Lesions may have associated pruritus (beyond insane pruritus) and scale and the characteristically exhibit rapid migration
- When 2 rings meet, they do not intersect → resulting in polycyclic appearance
- Concentric erythematous lesions
- Appearence of wood grains
Pathology
- Non specific
- Hyperkeratosis, focal parakeratosis, patchy spongiosis, perivascular lymphocytic infiltrate
DDx
- erythrokeratodermiia variabilis et progressiva
- Resolvig PRP
- Paraneoplastic bullous pemphigoid
- Epidermolysis bullosa acquisita
Treatment
- Cutaneous lesions resolve with successful treatment of the neoplasm
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