Common findings
- Photosensitivity
- Premature aging
- Malignancy risk
Maior risco de radiodermites
Radiodermites- Disorders of Defective DNA repair
- Decrease DNA protection from UV
- double-strand DNA breaks
- DNA helicase mutation
- Nucleotide excision repair (NER)
- mismatch repair (MMR) mechanisms → microsatellite instability
- lamin A (nuclear envelope)
- Inter strand cross-links Trichothiodystrophy & Cockayne Syndrome
- Rothmund-Thomson SyndromeBloom Syndrome
Werner Syndrome (≠ Wermer)
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