Superficial epidermolytic ichthyosis (Ichthyosis bullosa of Siemens)

  • KRT2 mutation
    • Cytolysis of granular cells
  • Erythroderma and superficial blistering at birth
  • Later, hyperkeratosis with accentuation over joints, flexures and dorsal hands/feet
  • “molting” of the skin
  • Palms and soles spared