Mal de Meleda and Gamborg-Nielsen/Norrbotten PPK

Clinical presentation
  • Erythematous, fissured, macerated, malodorous and transgressive KPP
  • Hyperhidrosis
  • Involvement of the back of the joints, koilonychia, subungueal hyperkeratosis and bacterial or viral superinfection are common
  • Autossomal recessive
  • Mutations in SLURP-1 gene