Tesaurismose Deposition of drug or metabolites thesaurismosis : thesauros in greek → treasure, store. Doença que implica a deposição de uma substância ou seu metabolito na pele. Mais abrangente.Distinguir de Ocronose Etiologia Exógena medicamento Amiodarone → purplish Quinolones Synthetic antimalarials Hydroxichloroquine Quinaquirne - lemmon yellow Chloroquine - blue-gray Minocycline Type 1: blue-gray pigmentation of old scars (acne, orthopedic) Type 2: diffuse blue-gray discoloration on normal skin, particularly front of the legs Type 3: diffuse brown pigmentation on sun-exposed areas Clofazimin (indicated for leprosy) Orange-red → brown discoloration of the skin, hair, eyes (conjunctive, cornea) Psychotropic drugs Phenotizines and tricyclic antidressants - gray-blue to purple pigmentation (accumulation) or orange-yellow (drug-induced phomelanin production) Bleomycin → flagellate dermatosis Dermatoses figuradas Relative deficiency of bleomycin hydroxylase in the skin, which causes the product to accumulate in situ, resulting in local inflammation and subsequent pigmentary incontinence (controversial) Supravenous serpiginous dermatosis Metals Argyria Chrysocyanosis - gold salts Hydrargyria - mercury containing preparations Endógena Homogentisic acid (alkaptonuria) Apresentação clínica Hyperpigmentation that persists with continuous long term use of hydroquinone Blue-greyish color Dermoscopy Globular amorphous structures around follicular openings Histology Banana figures in the dermis
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